Methyl iodide → 1H-1,2,4-Triazole, 4-methyl-3-(methylthio)-5-phenyl-
反応式
[CH3:1][N:2]1[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[N:5][NH:4][C:3]1=[S:13].[OH-].[Na+].[CH3:16]I>C(O)C>[CH3:1][N:2]1[C:3]([S:13][CH3:16])=[N:4][N:5]=[C:6]1[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1参加物
5
実験手順
To a stirred solution of 4-methyl-5-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione (5.0 g, 2.6×10-2 mole) and 1 molar aqueous NaOH (59 ml, 5.9×10-2 mole) was added a solution of methyl iodide (2.6 ml, 4.2×10-2 mole) and ethanol (13 ml). The reaction was stirred for 3 hours and it was then placed in the refrigerator. After standing in the refrigerator overnight, the precipitate was collected by filtration. Crystallization from isopropanol afforded colorless needles, Mp 134°-135° C.
後処理
- customAfter standing in the refrigerator overnight
- filtrationthe precipitate was collected by filtration
- customCrystallization from isopropanol afforded colorless needles, Mp 134°-135° C.
出典と根拠
- ORDレコード
- ord-c3de5ba86af34e74887cb39df6a49b6e
- 出典データセット
- uspto-grants-1992_10
- 特許番号
- US05158968
反応ノート
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