Water → Epiandrosterone

HRID 467451

反応式

HRID 467451 の反応式
C([O:4][C@H:5]1[CH2:22][CH2:21][C@@:20]2([CH3:23])[C@@H:7]([CH2:8][CH2:9][C@@H:10]3[C@@H:19]2[CH2:18][CH2:17][C@@:15]2([CH3:16])[C@H:11]3[CH2:12][CH2:13][C:14]2=[O:24])[CH2:6]1)(=O)C.[OH-].[Na+].O>CO>[OH:4][C@H:5]1[CH2:22][CH2:21][C@@:20]2([CH3:23])[C@@H:7]([CH2:8][CH2:9][C@@H:10]3[C@@H:19]2[CH2:18][CH2:17][C@@:15]2([CH3:16])[C@H:11]3[CH2:12][CH2:13][C:14]2=[O:24])[CH2:6]1

参加物

5

反応物 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 9087403beta-Acetoxy-5alpha-androstan-17-one

生成物 1

HCID 441302Epiandrosterone収率 95%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 5 (1 g, 3.00 mmol), NaOH 0.12 g (3.44 mmol) in methanol was refluxed for 10 min, cooled to room temperature and treated with water. The resulting precipitate was filtered off and washed with water to afford crude product 6 (0.82 g, 95%).

後処理

  1. temperaturewas refluxed for 10 min
  2. filtrationThe resulting precipitate was filtered off
  3. washwashed with water

出典と根拠

ORDレコード
ord-ae5f46f7bef043fb87e21b3a77341060
出典データセット
uspto-grants-2014_01
特許番号
US08623849B2

関連ノート

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