Sodium Hydroxide → AN-465/43411221

HRID 46774

反応式

HRID 46774 の反応式
Br.[CH2:2]([NH:10][CH2:11][CH2:12][C:13]1[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[C:15]([O:21][CH3:22])[CH:14]=1)[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[OH-].[Na+]>O>[CH2:2]([NH:10][CH2:11][CH2:12][C:13]1[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[C:15]([O:21][CH3:22])[CH:14]=1)[CH2:3][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 30486862-(3,4-Dimethoxyphenyl)-N-(2-phenylethyl)ethan-1-amine--hydrogen bromide (1/1)

生成物 1

HCID 215356AN-465/43411221収率 97.5%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
0 °C

実験手順

25 g of the latter hydrobromide were dissolved in 250 ml of hot water and the solution was cooled to 0° C. and made alkaline with 40 ml of 2 N sodium hydroxide. The mixture was extracted 3 times with 100 ml of ethyl acetate and the organic extracts were washed with water until the wash water had a pH of 7 to 8. The extracts were dried over sodium sulfate, were filtered and evaporated to dryness under reduced pressure to obtain 19 g of N-phenethyl-3,4-dimethoxyphenethylamine.

後処理

  1. extractionThe mixture was extracted 3 times with 100 ml of ethyl acetate
  2. washthe organic extracts were washed with water until the wash water
  3. dry with materialThe extracts were dried over sodium sulfate
  4. filtrationwere filtered
  5. customevaporated to dryness under reduced pressure

出典と根拠

ORDレコード
ord-667f98f9fa514bd293cae9b10b6fc01d
出典データセット
uspto-grants-1979_11
特許番号
US04175136

関連ノート

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