Acetic Acid → S-Ethyl-L-cysteine

HRID 468039

反応式

HRID 468039 の反応式
Cl.[NH2:2][C@H:3]([C:6]([OH:8])=[O:7])[CH2:4][SH:5].[CH2:9](Br)[CH3:10].O.N.C(O)(=O)C>O>[CH2:9]([S:5][CH2:4][C@@H:3]([C:6]([OH:8])=[O:7])[NH2:2])[CH3:10]

参加物

6

反応物 4

HCID 176Acetic AcidHCID 6332Ethyl BromideHCID 60960Cysteine HydrochlorideHCID 12896473Azane;hydrate

生成物 1

HCID 92185S-Ethyl-L-cysteine

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

SEC is synthesized from L-cysteine hydrochloride (1.58 g, 0.01 mol) and ethyl bromide (1.09 g, 0.01 mol) with the following steps. The reaction mixture is diluted with water in a titration manner until a clear solution is formed. No more than necessary amount of water should be added to further dilute the mixture. Ammonia water was added to PH 9.5-10 with stirring at room temperature. After 2 hours reaction, the mixture is acidified with acetic acid to PH 5-5.5. The desired product was cooled in the refrigerator, filtered and washed successively with water and ethyl ether. The chemical structure of SEC is determined by Proton Nuclear Magnetic Resonance Spectroscopy.

後処理

  1. customis formed
  2. additionto further dilute the mixture
  3. customAfter 2 hours reaction

出典と根拠

ORDレコード
ord-5bc938180df9479d8bd30e80dc1a8e4b
出典データセット
uspto-grants-2014_01
特許番号
US08623919B2

関連ノート

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