1,1'-Carbonyldiimidazole → HCID 58393033、化合物

HRID 469017ノート

反応式

HRID 469017 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH3:9])[C:6]([S:10]([N:13]([CH2:15][C:16]2[O:20][CH:19]=[C:18]([C:21](O)=[O:22])[CH:17]=2)[CH3:14])(=[O:12])=[O:11])=[C:5]([CH3:24])[CH:4]=1.C1N=CN(C(N2C=NC=C2)=O)C=1.[CH3:37][NH:38][CH2:39][C:40]1[CH:45]=[CH:44][C:43]([C:46]2[CH:47]=[N:48][CH:49]=[N:50][CH:51]=2)=[CH:42][CH:41]=1>C1COCC1.CN(C=O)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH3:24])[C:6]([S:10]([N:13]([CH2:15][C:16]2[O:20][CH:19]=[C:18]([C:21]([N:38]([CH3:37])[CH2:39][C:40]3[CH:41]=[CH:42][C:43]([C:46]4[CH:51]=[N:50][CH:49]=[N:48][CH:47]=4)=[CH:44][CH:45]=3)=[O:22])[CH:17]=2)[CH3:14])(=[O:12])=[O:11])=[C:7]([CH3:9])[CH:8]=1

参加物

6

反応物 3

HCID 682631,1'-CarbonyldiimidazoleHCID 7162045N-methyl-N-(4-pyrimidin-5-ylbenzyl)amineHCID 583930975-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)furan-3-carboxylic acid

生成物 1

HCID 58393033HCID 58393033、化合物

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

The title compound was prepared according to general procedure AA using 5-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)furan-3-carboxylic acid (75 mg, 0.21 mmol), CDI (41 mg, 0.25 mmol) and N-methyl-1-[4-(pyrimidin-5-yl)phenyl]methanamine (42 mg, 0.21 mmol) in THF (4.5 mL) and DMF (0.6 mL). The crude product was purified using prep method A.

後処理

  1. customThe crude product was purified

出典と根拠

ORDレコード
ord-809eccb29b7b461db782bc68b5abb7f5
出典データセット
uspto-grants-2014_01
特許番号
US08623859B2

反応ノート

読み込み中…