1-((1-Methyl-4-piperidinyl)methyl)piperazine → 4-Methoxy-N,2,6-trimethyl-N-{[5-({4-[(1-methylpiperidin-4-yl)methyl]piperazin-1-yl}carbonyl)-1,3,4-thiadiazol-2-yl]methyl}benzenesulfonamide

HRID 469129

反応式

HRID 469129 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH3:9])[C:6]([S:10]([N:13]([CH2:15][C:16]2[S:20][C:19]([C:21]([O:23]C)=O)=[N:18][N:17]=2)[CH3:14])(=[O:12])=[O:11])=[C:5]([CH3:25])[CH:4]=1.[CH3:26][N:27]1[CH2:32][CH2:31][CH:30]([CH2:33][N:34]2[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]2)[CH2:29][CH2:28]1.C[Al](C)C>C1COCC1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH3:25])[C:6]([S:10]([N:13]([CH3:14])[CH2:15][C:16]2[S:20][C:19]([C:21]([N:37]3[CH2:36][CH2:35][N:34]([CH2:33][CH:30]4[CH2:31][CH2:32][N:27]([CH3:26])[CH2:28][CH2:29]4)[CH2:39][CH2:38]3)=[O:23])=[N:18][N:17]=2)(=[O:12])=[O:11])=[C:7]([CH3:9])[CH:8]=1

参加物

5

反応物 3

HCID 27369421-((1-Methyl-4-piperidinyl)methyl)piperazineHCID 16682925TrimethylaluminumHCID 58392977Methyl 5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-1,3,4-thiadiazole-2-carboxylate

生成物 1

HCID 583929874-Methoxy-N,2,6-trimethyl-N-{[5-({4-[(1-methylpiperidin-4-yl)methyl]piperazin-1-yl}carbonyl)-1,3,4-thiadiazol-2-yl]methyl}benzenesulfonamide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

The title compound was prepared according to general procedure BK using methyl 5-({[(4-methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)-1,3,4-thiadiazole-2-carboxylate (100 mg, 0.26 mmol), 1-(1-methyl-piperidin-4-ylmethyl)-piperazine (61 mg, 0.31 mmol), trimethylaluminium (2 M in toluene, 0.28 mL) and THF (10 mL).

出典と根拠

ORDレコード
ord-a35e4764f7194401a85b086089a05653
出典データセット
uspto-grants-2014_01
特許番号
US08623859B2

関連ノート

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