Methanethiol → Ethyl 2-[(methylsulfanyl)methyl]prop-2-enoate

HRID 46925

反応式

HRID 46925 の反応式
[CH3:1][SH:2].[Na].[CH2:4]([O:6][C:7](=[O:12])[C:8]([CH2:10]Br)=[CH2:9])[CH3:5]>C(O)C.O>[CH2:4]([O:6][C:7](=[O:12])[C:8]([CH2:10][S:2][CH3:1])=[CH2:9])[CH3:5]

参加物

6

反応物 3

HCID 878MethanethiolHCID 3106202-(Bromomethyl)acrylic acid ethyl esterHCID 5360545Sodium

生成物 1

HCID 12463627Ethyl 2-[(methylsulfanyl)methyl]prop-2-enoate

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒2 回HCID 962Water溶媒

実験手順

A solution of methylmercaptan (4.8 g.) and sodium (2.3 g.) in absolute ethanol (75 ml.) is added dropwise to a solution of ethyl-2-bromomethylacrylate (19.3 g.) in ethanol (25 ml.). After two hours, it is diluted with water (400 ml.) and extracted with methylene chloride. The organic layer is dried and concentrated to dryness in vacuo to yield ethyl-2-methylthiomethylacrylate.

後処理

  1. extractionextracted with methylene chloride
  2. customThe organic layer is dried
  3. concentrationconcentrated to dryness in vacuo

出典と根拠

ORDレコード
ord-ef169ab13b9c4ed390f40d30a51c76c2
出典データセット
uspto-grants-1979_11
特許番号
US04175199

関連ノート

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