1-Propanol → 2-Methyl-4-propoxypyridine-1-oxide
反応式
[Na].[CH3:2][C:3]1[CH:8]=[C:7]([N+]([O-])=O)[CH:6]=[CH:5][N+:4]=1[O-:12].[CH2:13]([OH:16])[CH2:14][CH3:15]>>[CH3:2][C:3]1[CH:8]=[C:7]([O:16][CH2:13][CH2:14][CH3:15])[CH:6]=[CH:5][N+:4]=1[O-:12]参加物
4
実験手順
To a solution of sodium n-propoxide solution prepared by dissolving sodium (1.7 g) in n-propanol (200 ml) was added to a hot solution of 2-methyl-4-nitropyridine-1-oxide (5.2 g) in n-propanol (210 ml). The mixture was stirred for ten minutes, then n-propanol was evaporated off. To the residue was added chloroform under ice-cooling, and insoluble materials were removed by means of celite filtration. From the resultant solution was removed chloroform by evaporation. The residue was subjected to a silica-gel column chromatography, followed by elution with 10% methanol-chloroform to yield 2-methyl-4-propoxypyridine-1-oxide (4.7 g) as an oily substance.