Tetrahydrofuran → 4-amino-N,N,2-trimethylbenzamide

HRID 469825ノート

反応式

HRID 469825 の反応式
[CH3:1][C:2]1[CH:12]=[C:11]([N+:13]([O-])=O)[CH:10]=[CH:9][C:3]=1[C:4]([N:6]([CH3:8])[CH3:7])=[O:5].C1COCC1>CO.[Pd]>[NH2:13][C:11]1[CH:10]=[CH:9][C:3]([C:4]([N:6]([CH3:8])[CH3:7])=[O:5])=[C:2]([CH3:1])[CH:12]=1

参加物

5

反応物 2

HCID 8028TetrahydrofuranHCID 62604610N,N,2-trimethyl-4-nitrobenzamide

生成物 1

HCID 536229124-amino-N,N,2-trimethylbenzamide

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A solution of 1.7 g (8.16 mmol) 2,N,N-trimethyl-4-nitro-benzamide in 45 ml MeOH:THF=1:1 is hydrogenated in the presence of 0.2 g 10% Pd/C (Fluka 75990). The reaction mixture is filtered (2 glass fiber filters used) and the filtrate is concentrated in vacuo to afford the crude title compound.

後処理

  1. filtrationThe reaction mixture is filtered (2 glass fiber filters used)
  2. concentrationthe filtrate is concentrated in vacuo

出典と根拠

ORDレコード
ord-8cd8849841184a608b42eb6ad4f7817e
出典データセット
uspto-grants-2014_01
特許番号
US08629168B2

反応ノート

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