Tetrahydrofuran → 4-[4-(2-Methoxy-ethyl)-piperazin-1-yl]-3-methyl-phenylamine

HRID 469832ノート

反応式

HRID 469832 の反応式
[CH3:1][O:2][CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][N:8]([C:11]2[CH:16]=[CH:15][C:14]([N+:17]([O-])=O)=[CH:13][C:12]=2[CH3:20])[CH2:7][CH2:6]1.C1COCC1>CO.[Pd]>[CH3:1][O:2][CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][N:8]([C:11]2[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][C:12]=2[CH3:20])[CH2:7][CH2:6]1

参加物

5

反応物 2

HCID 8028TetrahydrofuranHCID 674588251-(2-Methoxy-ethyl)-4-(2-methyl-4-nitro-phenyl)-piperazine

生成物 1

HCID 666173884-[4-(2-Methoxy-ethyl)-piperazin-1-yl]-3-methyl-phenylamine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A solution of 0.85 g (3.04 mmol) 1-(2-methoxy-ethyl)-4-(2-methyl-4-nitro-phenyl)-piperazine in 20 ml MeOH:THF=1:1 is hydrogenated in the presence of 0.2 g 10% Pd/C (Engelhard 4505). The reaction mixture is filtered (2 glass fiber filters used) and the filtrate is concentrated in vacuo to afford the title compound as an oil.

後処理

  1. filtrationThe reaction mixture is filtered (2 glass fiber filters used)
  2. concentrationthe filtrate is concentrated in vacuo

出典と根拠

ORDレコード
ord-5cf1bcbbf98a4561a3630887a21c097b
出典データセット
uspto-grants-2014_01
特許番号
US08629168B2

反応ノート

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