3-Chloro-2-methyl-1-propene → 1-(3,3-Dimethylcyclohexyl)ethanone

HRID 46999

反応式

HRID 46999 の反応式
[OH-].[K+].[C:3]([CH:6]1[CH2:11][CH2:10][CH2:9][C:8]([CH3:13])([CH3:12])[CH2:7]1)(=[O:5])[CH3:4].C1OCCOC2C(=CC=CC=2)OCCOCCOC2C(=CC=CC=2)OC1.[CH2:40](Cl)[C:41](=[CH2:43])[CH3:42]>O.C1(C)C=CC=CC=1>[C:3]([CH:6]1[CH2:11][CH2:10][CH2:9][C:8]([CH3:13])([CH3:12])[CH2:7]1)(=[O:5])[CH3:4].[C:3]([C:6]1([CH2:42][C:41]([CH3:43])=[CH2:40])[CH2:11][CH2:10][CH2:9][C:8]([CH3:13])([CH3:12])[CH2:7]1)(=[O:5])[CH3:4]

参加物

8

反応物 4

HCID 112413-Chloro-2-methyl-1-propeneHCID 14797Potassium HydroxideHCID 26541Dibenzo-18-crown-6HCID 913881-(3,3-Dimethylcyclohexyl)ethanone

生成物 2

HCID 913881-(3,3-Dimethylcyclohexyl)ethanoneHCID 203846051-Acetyl-3,3-dimethyl-1-(2-methyl-2-propenyl)cyclohexane

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 1140Toluene溶媒

反応条件

温度
70 °C

実験手順

A slurry of potassium hydroxide (84 grams, 1.5 moles), 1-acetyl-3,3,-dimethylcyclohexane (156 grams, 1 mole), dibenzo-18-crown-6 (3 grams) having the structure: ##STR19## produced by the Aldrich Chemical Company of Metuchen, New Jersey, and toluene (150 ml) is heated to reflux whereupon the reaction mass thickens. The mass is cooled to 70° C., and methallyl chloride (135 grams, 1.5 moles) is added thereto rendering the reaction mixture more fluid. The reaction mixture is heated at reflux for an additional 9 hours whereupon the mass is cooled, and water is added. The aqueous layer is decanted and the organic layer is distilled to afford 1-acetyl-3,3-dimethylcyclohexane (62 gm) and 1-acetyl-3,3-dimethyl-1-(2-methyl-2-propenyl) cyclohexane (83 gm, NMR spectrum, FIG. 1; IR spectrum, FIG. 2).

後処理

  1. temperatureis heated
  2. temperatureto reflux whereupon the reaction mass thickens
  3. temperatureThe reaction mixture is heated
  4. temperatureat reflux for an additional 9 hours whereupon the mass
  5. temperatureis cooled
  6. customThe aqueous layer is decanted
  7. distillationthe organic layer is distilled

出典と根拠

ORDレコード
ord-2d55afd2eec148be9d6aefce45d24778
出典データセット
uspto-grants-1979_11
特許番号
US04175569

関連ノート

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