4-Ethylpyridin-2-amine → 4-Ethyl-5-iodopyridin-2-amine

HRID 471393

反応式

HRID 471393 の反応式
[CH2:1]([C:3]1[CH:8]=[CH:7][N:6]=[C:5]([NH2:9])[CH:4]=1)[CH3:2].C1C(=O)N([I:17])C(=O)C1>>[CH2:1]([C:3]1[C:8]([I:17])=[CH:7][N:6]=[C:5]([NH2:9])[CH:4]=1)[CH3:2]

参加物

3

反応物 2

HCID 1184254-Ethylpyridin-2-amineHCID 120273N-Iodosuccinimide

生成物 1

HCID 582005784-Ethyl-5-iodopyridin-2-amine

実験手順

The title compound is synthesized according to general procedure GP1 starting from 5.0 g (41 mmol) 4-ethyl-pyridin-2-ylamine and 9.2 g (41 mmol) NIS. Yield after precipitation from the reaction mixture and isolation of additional product from the mother liquid by chromatography using silica gel: 10.3 g (100%).

後処理

  1. customYield
  2. customafter precipitation from the reaction mixture and isolation of additional product from the mother liquid by chromatography

出典と根拠

ORDレコード
ord-2c7b77c81fe6431e91dfa4bc4768f366
出典データセット
uspto-grants-2014_01
特許番号
US08633183B2

関連ノート

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