Nitric Acid → HCID 178512554、化合物

HRID 47202ノート

反応式

HRID 47202 の反応式
[F:1][C:2]1[CH:8]=[C:7]([F:9])[CH:6]=[CH:5][C:3]=1[NH2:4].[N+:10]([O-:13])([OH:12])=[O:11].[N:14]#[C:15][NH2:16]>CCO>[N+:10]([O-:13])([OH:12])=[O:11].[F:1][C:2]1[CH:8]=[C:7]([F:9])[CH:6]=[CH:5][C:3]=1[NH:4][C:15]([NH2:16])=[NH:14]

参加物

5

反応物 3

HCID 944Nitric AcidHCID 97092,4-DifluoroanilineHCID 9864Cyanamide

生成物 1

HCID 178512554HCID 178512554、化合物収率 40%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a mixture of 2,4-difluoroaniline (25 mmol, 3.2 g) in EtOH (10 mL) in an ice bath was added nitric acid (69% aq soln.; 1.8 mL) dropwise. After completion of the addition cyanamide (50% aq. soln.; 4 mL) was added. The reaction mixture was refluxed under N2 for 22 h. The solvent was evaporated. The solid residue was washed with EtOH and was dried under high vacuum to afford the title compound as a purple solid (2.32 g, 40%).

後処理

  1. additionwas added
  2. temperatureThe reaction mixture was refluxed under N2 for 22 h
  3. customThe solvent was evaporated
  4. washThe solid residue was washed with EtOH
  5. customwas dried under high vacuum

出典と根拠

ORDレコード
ord-f864972e90794ee39827fc1c7b384905
出典データセット
uspto-grants-2004_03
特許番号
US06699854B2

反応ノート

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