反応式
[Cl:1][C:2]1[C:7]([CH:8]=[N:9]O)=[C:6]([Cl:11])[N:5]=[CH:4][N:3]=1.O=S(Cl)Cl>C(Cl)(Cl)Cl>[Cl:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([Cl:11])[N:5]=[CH:4][N:3]=1参加物
4
実験手順
4,6-Dichloro-5-pyrimidinecarbaldehyde oxime (8 g) was dissolved in CHCl3 (40 mL) and treated with SOCl2 (6 mL) for 2 h at rt. The solvent was removed and the residue was dissolved in DCM (5 mL). The resulting solid was filtered and washed with DCM (5 mL). The filtrate was concentrated under reduced pressure and purified by silica gel column chromatography using DCM-hexane (3:1) to give 4,6-dichloro-5-pyrimidinecarbonitrile as a white solid.
後処理
- customThe solvent was removed
- dissolutionthe residue was dissolved in DCM (5 mL)
- filtrationThe resulting solid was filtered
- washwashed with DCM (5 mL)
- concentrationThe filtrate was concentrated under reduced pressure
- custompurified by silica gel column chromatography
出典と根拠
- ORDレコード
- ord-2b9a09bac4be41d5a9ac0c90a8a45de4
- 出典データセット
- uspto-grants-2014_01
- 特許番号
- US08633313B2
関連ノート
読み込み中…