Sodium borohydride → (2-Fluoro-4-iodopyridin-3-yl)methanol

HRID 47359ノート

反応式

HRID 47359 の反応式
[BH4-].[Na+].[F:3][C:4]1[C:9]([CH:10]=[O:11])=[C:8]([I:12])[CH:7]=[CH:6][N:5]=1>O1CCCC1>[F:3][C:4]1[C:9]([CH2:10][OH:11])=[C:8]([I:12])[CH:7]=[CH:6][N:5]=1

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 99923282-Fluoro-4-iodopyridine-3-carbaldehyde

生成物 1

HCID 11021396(2-Fluoro-4-iodopyridin-3-yl)methanol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

0.72 g (19.2 mmol) of sodium borohydride is added to a solution of 4 g (16 mmol) of 2-fluoro-4-iodo-3-pyridinecarbaldehyde (described in J.O.C., 1993, 58, pp. 7832) in 100 ml of tetrahydrofuran. The mixture is stirred at room temperature for 4 hours and then hydrolysed. The reaction mixture is extracted with ethyl acetate. The organic phases are dried and concentrated to yield the expected product.

後処理

  1. extractionThe reaction mixture is extracted with ethyl acetate
  2. customThe organic phases are dried
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-d094e11700ea421e989ed6c166b22473
出典データセット
uspto-grants-2004_03
特許番号
US06699876B2

反応ノート

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