Trifluoroacetic acid → 5,7-Dichloro-4-(4-fluorophenyl)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid ethyl ester
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[C:7]([Cl:9])[CH:8]=1)[NH2:5].[CH2:10]([C:12](=O)[C:13]([O-:15])=[O:14])[CH3:11].[F:17][C:18]1[CH:25]=[CH:24][C:21](C=C)=[CH:20][CH:19]=1.F[C:27](F)(F)[C:28](O)=O>C(#N)C>[CH2:27]([O:15][C:13]([CH:12]1[CH2:10][CH:11]([C:21]2[CH:24]=[CH:25][C:18]([F:17])=[CH:19][CH:20]=2)[C:3]2[C:4](=[CH:6][C:7]([Cl:9])=[CH:8][C:2]=2[Cl:1])[NH:5]1)=[O:14])[CH3:28]参加物
6
実験手順
Compound 30 was prepared by the basic process from 5.0 mmol 3,5-dichloroaniline, 5.5 mmol ethylglyoxalate solution (50% toluene), 15.0 mmol 4-fluorostyrene and 5.0 mmol trifluoroacetic acid in 30.0 ml acetonitrile.
出典と根拠
- ORDレコード
- ord-ae3a24265ccf4681a0eaf5c40c4b7c82
- 出典データセット
- uspto-grants-2004_03
- 特許番号
- US06699877B2
反応ノート
読み込み中…