Diisopropylethylamine → HCID 71272215、化合物

HRID 475295

反応式

HRID 475295 の反応式
Cl[C:2]1[N:7]=[C:6]([NH:8][C:9]2[CH:13]=[C:12]([CH:14]3[CH2:16][CH2:15]3)[NH:11][N:10]=2)[CH:5]=[CH:4][N:3]=1.[CH3:17][N:18]1[C:26]2[C:21](=[CH:22][C:23]([CH2:27][NH2:28])=[CH:24][CH:25]=2)[CH:20]=[CH:19]1.CCN(C(C)C)C(C)C>CC(O)C>[CH:14]1([C:12]2[NH:11][N:10]=[C:9]([NH:8][C:6]3[CH:5]=[CH:4][N:3]=[C:2]([NH:28][CH2:27][C:23]4[CH:22]=[C:21]5[C:26](=[CH:25][CH:24]=4)[N:18]([CH3:17])[CH:19]=[CH:20]5)[N:7]=3)[CH:13]=2)[CH2:16][CH2:15]1

参加物

5

反応物 3

HCID 81531DiisopropylethylamineHCID 18525752(1-methyl-1H-indol-5-yl)methylamineHCID 58169118HCID 58169118、化合物

生成物 1

HCID 71272215HCID 71272215、化合物

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

反応条件

温度
120 °C

実験手順

A microwave vial was charged with 2-chloro-N-(5-cyclopropyl-1H-pyrazol-3-yl)pyrimidin-4-amine (160 mg, 0.68 mmol), 296 (800 mg, 5.59 mmol), DIPEA (1 ml), and IPA (5.0 mL), sealed and heated at 120° C. for 18 h. It was concentrated and purified by SiO2 chromatography, and then preparative HPLC to afford 30 mg (12%) of I-33 as white solid.

後処理

  1. customsealed
  2. concentrationIt was concentrated
  3. custompurified by SiO2 chromatography
  4. custompreparative HPLC to afford 30 mg (12%) of I-33 as white solid

出典と根拠

ORDレコード
ord-f0bb7d6be6034ea0984653c6e25a8990
出典データセット
uspto-grants-2014_01
特許番号
US08637537B2

関連ノート

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