Isopropylamine → 1-(2-Chloro-4-isopropylaminopyrimidin-5-yl)-ethanone

HRID 475322ノート

反応式

HRID 475322 の反応式
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5]([C:9](=[O:11])[CH3:10])=[CH:4][N:3]=1.C(=O)([O-])O.[Na+].[CH:17]([NH2:20])([CH3:19])[CH3:18].C1CCCCC1>C1COCC1>[Cl:1][C:2]1[N:7]=[C:6]([NH:20][CH:17]([CH3:19])[CH3:18])[C:5]([C:9](=[O:11])[CH3:10])=[CH:4][N:3]=1

参加物

6

反応物 4

HCID 6363IsopropylamineHCID 8078CyclohexaneHCID 516892Sodium BicarbonateHCID 212747081-(2,4-Dichloropyrimidin-5-yl)ethan-1-one

生成物 1

HCID 574611371-(2-Chloro-4-isopropylaminopyrimidin-5-yl)-ethanone

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

1-(2,4-dichloro-pyrimidin-5-yl)-ethanone (10 g, 0.052 mol), sodium hydrogen carbonate (19.35 g, 0.058 mol) and isopropylamine (5 mL, 0.058 mol) are taken up in 35 mL THF and 200 mL cyclohexane and stirred for 2 h at 20° C. The reaction solution is filtered through silica gel, the solvent is eliminated in vacuo and 1-(2-chloro-4-isopropylaminopyrimidin-5-yl)-ethanone (HPLC-MS: tRet.=1.73 min, MS(M+H)+=214/216; method FECB3) is obtained.

後処理

  1. filtrationThe reaction solution is filtered through silica gel

出典と根拠

ORDレコード
ord-68033b788dce4a37b212e189f222e7ac
出典データセット
uspto-grants-2014_01
特許番号
US08637549B2

反応ノート

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