Dimethylformamide → HCID 86762272、化合物
反応式
[C:1](C1SC=CN=1)([O:3][C:4](C)(C)[CH3:5])=[O:2].C(O[C:16]([C:18]1[N:19]=[C:20]([NH:23][C:24]([C:26]2[N:27]=[C:28]([NH:31][C:32]([O:34][C:35]([CH3:38])([CH3:37])[CH3:36])=[O:33])[S:29][CH:30]=2)=[O:25])[S:21][CH:22]=1)=[O:17])C.C(O)(C(F)(F)F)=O.[S:46]1[CH:50]=[CH:49][N:48]=[CH:47]1.C[N:52](C=O)C>>[CH2:4]([O:3][C:1]([C:49]1[N:48]=[C:47]([NH:52][C:16]([C:18]2[N:19]=[C:20]([NH:23][C:24]([C:26]3[N:27]=[C:28]([NH:31][C:32]([O:34][C:35]([CH3:36])([CH3:37])[CH3:38])=[O:33])[S:29][CH:30]=3)=[O:25])[S:21][CH:22]=2)=[O:17])[S:46][CH:50]=1)=[O:2])[CH3:5]参加物
6
実験手順
The Boc thiazole dimer (40) (0.281 g, 0.71 mmol) was deprotected using 95% TFA as described in general procedure D. The resulting residue (40′) was dissolved in dry DMF (5 mL) and the Boc protected thiazole acid (37) (0.172 g, 0.71 mmol) was added and reacted as described in general procedure B. This yielded a yellow foam 0.193 g (52%). LCMS (method 1) rt=3.88 min; m/z (ES+) 524 (M+1).