Chloroacetonitrile → 2-[[2-(6-methoxy-1H-indol-3-yl)-ethyl]-amino]-acetonitrile

HRID 476878

反応式

HRID 476878 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:12](=[CH:13][CH:14]=1)[C:8]([CH2:9][CH2:10][NH2:11])=[CH:7][NH:6]2.[CH2:15]([N:17](CC)CC)[CH3:16].ClCC#N>O1CCCC1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:12]([C:8]([CH2:9][CH2:10][NH:11][CH2:16][C:15]#[N:17])=[CH:7][NH:6]2)=[CH:13][CH:14]=1

参加物

5

反応物 3

HCID 7856ChloroacetonitrileHCID 8471TriethylamineHCID 176542-(2-Aminoethyl)-5-methoxyindole

生成物 1

HCID 198370192-[[2-(6-methoxy-1H-indol-3-yl)-ethyl]-amino]-acetonitrile

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

28.5 g of 6-methoxytryptamine were refluxed in 300 ml of tetrahydrofuran in the presence of 42 ml of triethylamine and 11.4 ml of chloroacetonitrile were added over 2 hours. The heating was continued for 1 hour and after allowing the temperature to return to the ambient, the precipitate was eliminated by filtration. The filtrate was concentrated to dryness under reduced pressure and the residue was taken up in ethyl acetate, washed with water, dried and the solvent was eliminated under reduced pressure to obtain 17.9 g of the expected product melting at approx. 80° C.

後処理

  1. additionwere added over 2 hours
  2. filtrationthe precipitate was eliminated by filtration
  3. concentrationThe filtrate was concentrated to dryness under reduced pressure
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-b6a94d5dd8734371acbf505ffefe1648
出典データセット
uspto-grants-1989_12
特許番号
US04886802

関連ノート

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