Ethyl Acetate → 4,4'-Dimethoxybenzophenone O-(3-ethoxycarbonyl-2-methoxyiminopropyl)oxime

HRID 477074ノート

反応式

HRID 477074 の反応式
[CH2:1]([O:3][C:4]([CH2:6][C:7](=O)[CH2:8][O:9][N:10]=[C:11]([C:20]1[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=1)[C:12]1[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=1)=[O:5])[CH3:2].Cl.[O:30]([NH2:32])[CH3:31].C(OCC)(=O)C>N1C=CC=CC=1>[CH2:1]([O:3][C:4]([CH2:6][C:7](=[N:32][O:30][CH3:31])[CH2:8][O:9][N:10]=[C:11]([C:20]1[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=1)[C:12]1[CH:13]=[CH:14][C:15]([O:18][CH3:19])=[CH:16][CH:17]=1)=[O:5])[CH3:2]

参加物

5

反応物 3

HCID 8857Ethyl AcetateHCID 521874O-Methylhydroxylamine hydrochlorideHCID 140527694,4'-dimethoxybenzophenone O-(3-ethoxycarbonyl-2-oxopropyl)oxime

生成物 1

HCID 538534414,4'-Dimethoxybenzophenone O-(3-ethoxycarbonyl-2-methoxyiminopropyl)oxime収率 96.6%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

3.85 g of the 4,4'-dimethoxybenzophenone O-(3-ethoxycarbonyl-2-oxopropyl)oxime as obtained in Example 1 was dissolved in 5 ml of pyridine and 1 g of methoxylamine hydrochloride was added thereto. Then the obtained mixture was stirred at room temperature. After two hours, the reaction mixture was poured into ethyl acetate, washed with diluted hydrochloric acid and then with a saturated saline solution and purified by silica gel chromatography. Thus 4 g of the title compound was obtained in the form of a colorless oily product.

後処理

  1. washwashed with diluted hydrochloric acid
  2. customwith a saturated saline solution and purified by silica gel chromatography

出典と根拠

ORDレコード
ord-5449c0e32a9949f1bd2fbec35972f8d6
出典データセット
uspto-grants-1989_12
特許番号
US04886834

反応ノート

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