Benzyl Chloride → 5-(benzylsulfanyl)-4H-1,2,4-triazol-3-amine

HRID 477732

反応式

HRID 477732 の反応式
[NH2:1][C:2]1[N:6]=[C:5]([SH:7])[NH:4][N:3]=1.[OH-].[Na+].[CH2:10](Cl)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C(O)C>[NH2:1][C:2]1[NH:3][N:4]=[C:5]([S:7][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:6]=1

参加物

5

反応物 3

HCID 7503Benzyl ChlorideHCID 14798Sodium HydroxideHCID 1785092965-amino-1H-1,2,4-triazole-3-thiol

生成物 1

HCID 7372725-(benzylsulfanyl)-4H-1,2,4-triazol-3-amine収率 90.6%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

3-Amino-5-mercapto-1,2,4-triazole (40.36 g) was treated at room temperature with sodium hydroxide (13.9 g) in ethanol (450 ml), and benzyl chloride (44.3 g) was added. The mixture was stirred overnight, and was then filtered. The ethanol was evaporated off, and the residue was recrystallised from ethyl acetate to give 64.97 g of the desired product, mp 104° C.

後処理

  1. additionwas added
  2. filtrationwas then filtered
  3. customThe ethanol was evaporated off
  4. customthe residue was recrystallised from ethyl acetate

出典と根拠

ORDレコード
ord-b82cfc36a6374223bdd0d890c06b2c86
出典データセット
uspto-grants-1989_12
特許番号
US04889553

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