Hydrogen Bromide → Ethanone, 2,2-dibromo-1-(3-pyridinyl)-, hydrobromide

HRID 480400

反応式

HRID 480400 の反応式
[C:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=1)(=[O:3])[CH3:2].[BrH:10].[Br:11]Br>O>[BrH:10].[Br:10][CH:2]([Br:11])[C:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=1)=[O:3]

参加物

5

反応物 3

HCID 260Hydrogen BromideHCID 95893-AcetylpyridineHCID 24408Bromine

生成物 1

HCID 11984074Ethanone, 2,2-dibromo-1-(3-pyridinyl)-, hydrobromide収率 99.4%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
57.5 °C

実験手順

3-Acetylpyridine (50 g, 0.41 mol), 47% aqueous HBr solution (106.6 g, 1.5 equivalent amount relative to 3-acetylpyridine) and water (80 ml) were charged in a reaction vessel and the mixture was stirred at 55-60° C. Bromine (135.2 g, 2.05 equivalent amount relative to 3-acetylpyridine) was added dropwise and the mixture was stirred for one more hour. The mixture was cooled to 5° C. under ice-cooling, and filtered to give 146.7 g of the titled compound as crystals (yield 99.0%).

後処理

  1. stirringthe mixture was stirred for one more hour
  2. temperatureThe mixture was cooled to 5° C. under ice-
  3. temperaturecooling
  4. filtrationfiltered

出典と根拠

ORDレコード
ord-3fe0c8d5b9e848c1b32e4410b9de3219
出典データセット
uspto-grants-2003_11
特許番号
US06649768B1

関連ノート

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