Hydrogen Bromide → Ethanone, 2,2-dibromo-1-(3-pyridinyl)-, hydrobromide
反応式
[C:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=1)(=[O:3])[CH3:2].[BrH:10].[Br:11]Br>O>[BrH:10].[Br:10][CH:2]([Br:11])[C:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][CH:9]=1)=[O:3]参加物
5
反応条件
- 温度
- 57.5 °C
実験手順
3-Acetylpyridine (50 g, 0.41 mol), 47% aqueous HBr solution (106.6 g, 1.5 equivalent amount relative to 3-acetylpyridine) and water (80 ml) were charged in a reaction vessel and the mixture was stirred at 55-60° C. Bromine (135.2 g, 2.05 equivalent amount relative to 3-acetylpyridine) was added dropwise and the mixture was stirred for one more hour. The mixture was cooled to 5° C. under ice-cooling, and filtered to give 146.7 g of the titled compound as crystals (yield 99.0%).
後処理
- stirringthe mixture was stirred for one more hour
- temperatureThe mixture was cooled to 5° C. under ice-
- temperaturecooling
- filtrationfiltered
出典と根拠
- ORDレコード
- ord-3fe0c8d5b9e848c1b32e4410b9de3219
- 出典データセット
- uspto-grants-2003_11
- 特許番号
- US06649768B1
反応ノート
読み込み中…