Trifluoroacetic acid → tert-Butyl 2-bromo-2-methylpropionate

HRID 48088

反応式

HRID 48088 の反応式
[CH2:1]=[C:2]([CH3:4])[CH3:3].[Br:5][C:6]([CH3:11])([CH3:10])[C:7]([OH:9])=[O:8].FC(F)(F)C(O)=O>C(Cl)Cl>[Br:5][C:6]([CH3:11])([CH3:10])[C:7]([O:9][C:2]([CH3:4])([CH3:3])[CH3:1])=[O:8]

参加物

5

反応物 3

HCID 6422Trifluoroacetic acidHCID 8255IsobutyleneHCID 749242-Bromo-2-methylpropanoic acid

生成物 1

HCID 90290tert-Butyl 2-bromo-2-methylpropionate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Isobutene is condensed into a solution of 2-bromo-2-methylpropanoic acid (10 mmol) and trifluoroacetic acid (1 mmol) in 100 mL of CH2Cl2 until the starting material is consumed, as observed by TLC. The volatile components are evaporated in vacuo, and the residue is filtered through a pad of neutral alumina using 50% ether/hexane. The filtrate is concentrated in vacuo and used without further purification.

後処理

  1. customis consumed
  2. customThe volatile components are evaporated in vacuo
  3. filtrationthe residue is filtered through a pad of neutral alumina using 50% ether/hexane
  4. concentrationThe filtrate is concentrated in vacuo
  5. customused without further purification

出典と根拠

ORDレコード
ord-5762bebda38142938f4f6eeb9c672c4b
出典データセット
uspto-grants-2004_03
特許番号
US06702705B1

関連ノート

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