tert-Butanol → Dimethyl 4-(2,6-dichlorophenyl)-2-(2-methoxy-2-oxoethyl)-6-[2-[2-[[2-(tritylamino)ethoxy]methyl]phenyl]ethyl]-1,4-dihydro-3,5-pyridinedicarboxylate

To a stirred solution of 2-methyl-2-propanol (1.25 g, 16.9 mmol) in anhydrous THF (50 ml) was added dropwise a 0.95 M solution of MeMgBr in THF (17.8 ml, 16.0 mmol) at room temperature under nitrogen atmosphere. The resulting solution was stirred at room temperature for 0.5 hour. Then to the mixture was added a solution of dimethyl 3-amino-2-pentenedioate (1.33 g, 7.66 mmol) in anhydrous THF (20 ml) dropwise at room temperature. The resulting pale yellow solution was stirred at the same temperature for 0.5 hour, then a solution of methyl 3-(2,6-dichlorophenyl)-2-[3-[2-[[2-(tritylamino)ethoxy]methyl]phenyl]propanoyl]-2-propenoate (6.38 mmol) in anhydrous THF (20 ml) was added at room temperature. The reaction mixture was stirred at room temperature for 8 h under nitrogen atmosphere, then acetic acid (3 ml) was added. The resulting mixture was stirred at room temperature for 16 hours. The mixture was poured into water, and the whole was extracted with ethyl acetate (20 ml×2). The combined organic layers were washed with 2N-HClaq. (50 ml) and sat.NaHCO3aq. (50 ml), dried over MgSO4 and concentrated to afford a crude mixture. Purification on silica gel column chromatography eluted with hexane/EtOAc (3/1) to afford the titled compound as a yellow amorphous. (3.80 g, 85%).

1. stirringThe resulting pale yellow solution was stirred at the same temperature for 0.5 hour
2. stirringThe reaction mixture was stirred at room temperature for 8 h under nitrogen atmosphere
3. stirringThe resulting mixture was stirred at room temperature for 16 hours
4. extractionthe whole was extracted with ethyl acetate (20 ml×2)
5. washThe combined organic layers were washed with 2N-HClaq
6. dry with material(50 ml), dried over MgSO4
7. concentrationconcentrated
8. customto afford a crude mixture
9. customPurification on silica gel column chromatography
10. washeluted with hexane/EtOAc (3/1)

ORDレコード

ord-22916626b5f14066bb012e1b692987d2

出典データセット

uspto-grants-2003_11

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US06653313B2