Chloroacetyl chloride → 2-Chloro-1-(4-mesitylpiperazin-1-yl)ethanone

HRID 481368

反応式

HRID 481368 の反応式
ClCC(N1CCN(C2C=CC=CC=2C)CC1)=O.[Cl:18][CH2:19][C:20](Cl)=[O:21].[CH3:23][C:24]1[CH:29]=[C:28]([CH3:30])[CH:27]=[C:26]([CH3:31])[C:25]=1[N:32]1[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]1.C(=O)([O-])[O-].[Ca+2]>CN(C)C=O.C(C(C)=O)C>[Cl:18][CH2:19][C:20]([N:35]1[CH2:36][CH2:37][N:32]([C:25]2[C:26]([CH3:31])=[CH:27][C:28]([CH3:30])=[CH:29][C:24]=2[CH3:23])[CH2:33][CH2:34]1)=[O:21]

参加物

7

反応物 4

HCID 6577Chloroacetyl chlorideHCID 10112Calcium CarbonateHCID 27608221-(2,4,6-Trimethylphenyl)piperazine2 回HCID 47412122-Chloro-1-(4-o-tolylpiperazin-1-yl)ethanone

生成物 1

HCID 47411712-Chloro-1-(4-mesitylpiperazin-1-yl)ethanone収率 96%

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒HCID 6569Methyl Ethyl Ketone溶媒

実験手順

Compound 52A is prepared according to the procedure described for compound 12A, using the following reactants: chloroacetyl chloride (480 ml, 6.05 mmol); 1-(2,4,6-trimethylphenyl)piperazine (31A) (1.122 g, 5.5 mmol); calcium carbonate (1.65 g, 16.5 mmol); methyl ethyl ketone (25 ml) and dimethylformamide (10 ml) to solubilize the 1-(2,4,6-trimethylphenyl)piperazine).

出典と根拠

ORDレコード
ord-f46ed88c3d404a2da382d30644ae8c66
出典データセット
uspto-grants-1998_08
特許番号
US05789412

関連ノート

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