反応式
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][N:8]=[CH:9]2)([O-])=O.I[CH2:15][CH2:16][CH3:17].[CH3:18][CH2:19][OH:20]>>[CH2:15]([N:8]1[CH2:7][CH2:6][C:5]2[C:10](=[CH:11][CH:12]=[CH:13][C:4]=2[NH:1][C:19](=[O:20])[CH3:18])[CH2:9]1)[CH2:16][CH3:17]参加物
4
実験手順
A solution of 5-nitroisoquinoline (25 g, 0.144 mol) and iodopropane (36.7 g, 0.216 mol) in 500 mL of EtOH was converted to the title compound by the procedures described in Example 1. The crude title compound was purified by chromatography (silica gel, 95:5 EtOAc:EtOH). The purified product was recrystallized from iPr2O/THF to give the title compound as a white solid (3.33 g, 18%), mp=123° C.
出典と根拠
- ORDレコード
- ord-6b284eb5fb784751a6f68a70a1b7e4ac
- 出典データセット
- uspto-grants-2004_03
- 特許番号
- US06703391B2
関連ノート
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