Hydantoin → 3-(4-Nitrobenzyl)imidazolidine-2,4-dione
反応式
[NH:1]1[CH2:7][C:5](=[O:6])[NH:4][C:2]1=[O:3].[OH-].[Na+].[N+:10]([C:13]1[CH:20]=[CH:19][C:16]([CH2:17]Br)=[CH:15][CH:14]=1)([O-:12])=[O:11]>CO>[N+:10]([C:13]1[CH:20]=[CH:19][C:16]([CH2:17][N:4]2[C:5](=[O:6])[CH2:7][NH:1][C:2]2=[O:3])=[CH:15][CH:14]=1)([O-:12])=[O:11]参加物
5
実験手順
A solution of hydantoin (5.0 g, Aldrich) in 2N aqu. NaOH (25 ml) was stirred at room temperature for 1 hour, then a solution of p-nitrobenzyl bromide (10.8 g, Aldrich) in methanol (50 ml) was added and the mixture refluxed for 16 hours. The mixture was cooled and the pale yellow precipitate filtered off, dried in vacuo, and recrystalised from ethanol to give the desired product as pale yellow crystals (6.8 g).
後処理
- temperaturethe mixture refluxed for 16 hours
- temperatureThe mixture was cooled
- filtrationthe pale yellow precipitate filtered off
- customdried in vacuo
- customrecrystalised from ethanol
出典と根拠
- ORDレコード
- ord-86d2fe63c1234c87a9d1b4441aa934dc
- 出典データセット
- uspto-grants-1993_07
- 特許番号
- US05225431
反応ノート
読み込み中…