Ethyl isobutyrate → Ethyl dimethylhexanoate

HRID 483429ノート

反応式

HRID 483429 の反応式
[Li+].[CH3:2][CH:3]([N-]C(C)C)[CH3:4].[C:9]([O:14][CH2:15][CH3:16])(=[O:13])[CH:10]([CH3:12])[CH3:11].[CH3:17]N(P(N(C)C)(N(C)C)=O)C.C(I)CCC>C1COCC1>[CH3:11][C:10]([CH3:17])([CH2:12][CH2:2][CH2:3][CH3:4])[C:9]([O:14][CH2:15][CH3:16])=[O:13]

参加物

6

反応物 4

HCID 7342Ethyl isobutyrateHCID 10962Butyl iodideHCID 12679HexamethylphosphoramideHCID 2724682Lithium diisopropylamide

生成物 1

HCID 3024116Ethyl dimethylhexanoate

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To LDA prepared at -78° C. in the usual manner was added ethyl isobutyrate (45 g) in THF, and stirred for 1 h. A dry HMPA solution of butyl iodide (107 g) was added, and the mixture was stirred at -78° C. for 1 h and then at room temperature for additional 1 h.

後処理

  1. stirringthe mixture was stirred at -78° C. for 1 h
  2. customat room temperature
  3. customfor additional 1 h.

出典と根拠

ORDレコード
ord-19ffc8a75b314d88b42a59b36c2bb2d9
出典データセット
uspto-grants-1993_07
特許番号
US05225439

反応ノート

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