2-Methyl-3-butyn-2-ol → 6-Hepten-3-yn-2-ol, 2,6-dimethyl-
反応式
[CH3:1][C:2]([OH:6])([C:4]#[CH:5])[CH3:3].Cl[CH2:8][C:9]([CH3:11])=[CH2:10].C(=O)([O-])[O-].[K+].[K+]>[Cl-].C([N+](CC)(CC)CC)C1C=CC=CC=1>[CH3:1][C:2]([OH:6])([C:4]#[C:5][CH2:10][C:9]([CH3:11])=[CH2:8])[CH3:3]参加物
5
実験手順
The coupling reaction was conducted in the manner described in the procedure of Example VI using the following reagents: 1.00 mL (10.3 mmoles) of 2-methyl-3-butyn-2-ol, 1.10 mL (11.1 mmoles) of 3-chloro-2-methylpropene, 2.34 g (16.9 mmoles) of anhydrous potassium carbonate, 89 mg (0.90 mmole) of cuprous chloride, and 165 mg (0.72 mmole) of benzyltriethylammonium chloride. Isolation of the product in the usual manner afforded 925 mg (65%) of the named alcohol, thereby demonstrating the lack of need for a solvent in this coupling reaction.
後処理
- customThe coupling reaction
出典と根拠
- ORDレコード
- ord-d17dfcd1bd7f4f7f934de630027e17ea
- 出典データセット
- uspto-grants-1993_07
- 特許番号
- US05231232
反応ノート
読み込み中…