Hydrogen Bromide → 1-Methyl-3-bromopropyldimethylamine hydrobromide

HRID 484837ノート

反応式

HRID 484837 の反応式
[CH3:1][CH:2]([N:12]([CH3:14])[CH3:13])[CH2:3][CH2:4]OC1C=CC=CC=1.[BrH:15]>C(Cl)(Cl)Cl>[BrH:15].[CH3:1][CH:2]([N:12]([CH3:14])[CH3:13])[CH2:3][CH2:4][Br:15]

参加物

4

反応物 2

HCID 260Hydrogen BromideHCID 201358801-Methyl-3-phenoxypropyldimethylamine

生成物 1

HCID 201357911-Methyl-3-bromopropyldimethylamine hydrobromide収率 79%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

5 g of the 1-methyl-3-phenoxypropyldimethylamine thus obtained was reacted with 30 ml of 40% hydrobromic acid at 150° C. for 7 hours with stirring. The reaction solution was cooled and added with 20 ml of chloroform, and then the hydrobromic acid layer was separated from the chloroform layer. The hydrobromic acid was removed under reduced pressure and the residue was recrystallized from 5 ml of ethyl alcohol to give 4.46 g of 1-methyl-3-bromopropyldimethylamine hydrobromide in a yield of 79%.

後処理

  1. temperatureThe reaction solution was cooled
  2. customthe hydrobromic acid layer was separated from the chloroform layer
  3. customThe hydrobromic acid was removed under reduced pressure
  4. customthe residue was recrystallized from 5 ml of ethyl alcohol

出典と根拠

ORDレコード
ord-ecee95e405c641be9d7c793c11162d63
出典データセット
uspto-grants-1985_08
特許番号
US04533731

反応ノート

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