Ethyl bromoacetate → Ethyl 3-benzoylamino-3-isobutyrylpropionate

HRID 485020ノート

反応式

HRID 485020 の反応式
[C:1]([NH:9][CH2:10][C:11](=[O:15])[CH:12]([CH3:14])[CH3:13])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Na+].Br[CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21]>>[C:1]([NH:9][CH:10]([C:11](=[O:15])[CH:12]([CH3:13])[CH3:14])[CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 3

HCID 7748Ethyl bromoacetateHCID 24758Sodium hydrideHCID 13490305N-(3-Methyl-2-oxobutyl)benzamide

生成物 1

HCID 13488802Ethyl 3-benzoylamino-3-isobutyrylpropionate収率 67.8%

実験手順

6.8 g of N-benzoylisobutyrylmethylamine, 1.56 g of 61% sodium hydride and 6.1 g of ethyl bromoacetate are treated in the same manner as described in Preparation 1-(5). 6.54 g of ethyl 3-benzoylamino-3-isobutyrylpropionate are thereby obtained. Yield: 67.7%.

後処理

  1. customas described in Preparation 1-(5)

出典と根拠

ORDレコード
ord-e5fa86c8490d4acb89ebe9e2e7f982c0
出典データセット
uspto-grants-1985_08
特許番号
US04535089

反応ノート

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