Formaldehyde → 4-[3-(1-Piperidinylmethyl)phenoxy]butanal

HRID 485376

反応式

HRID 485376 の反応式
[N:1]1([CH2:7][C:8]2[CH:9]=[C:10]([CH:21]=[CH:22][CH:23]=2)[O:11][CH2:12][CH2:13][CH2:14][CH:15]=NNC(N)=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C=O.C(=O)([O-])[O-:27].[Na+].[Na+]>Cl.O>[N:1]1([CH2:7][C:8]2[CH:9]=[C:10]([CH:21]=[CH:22][CH:23]=2)[O:11][CH2:12][CH2:13][CH2:14][CH:15]=[O:27])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

6

反応物 3

HCID 712FormaldehydeHCID 10340Sodium CarbonateHCID 540828474-[3-(1-Piperidinylmethyl)phenoxy]butanal semicarbazone

生成物 1

HCID 212975474-[3-(1-Piperidinylmethyl)phenoxy]butanal

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 962Water溶媒

実験手順

4-[3-(1-piperidinylmethyl)phenoxy]butanal semicarbazone (9.43 g) and 37% formaldehyde (80 ml) in 2N hydrochloric acid (80 ml) were stirred at room temperature for 2.5 h and then diluted with water. The solution was basified with sodium carbonate and extracted with ether. The organic extract was washed with brine, and distilled to give the title compound as a colourless oil (5.59 g) b.p. 200°, 0.06 mm; tlc methanol Rf 0.7.

後処理

  1. extractionextracted with ether
  2. extractionThe organic extract
  3. washwas washed with brine
  4. distillationdistilled

出典と根拠

ORDレコード
ord-838e4ec62b9849b5a1de5c6fa6cb6f77
出典データセット
uspto-grants-1985_08
特許番号
US04536508

関連ノート

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