Thionyl Chloride → 2-Methyl-2-(3-thienyl) propionic acid chloride
反応式
[CH3:1][C:2]([C:7]1[CH:11]=[CH:10][S:9][CH:8]=1)([CH3:6])[C:3](O)=[O:4].S(Cl)([Cl:14])=O>C(Cl)(Cl)Cl>[CH3:1][C:2]([C:7]1[CH:11]=[CH:10][S:9][CH:8]=1)([CH3:6])[C:3]([Cl:14])=[O:4]参加物
4
実験手順
The 2-methyl-2-(3-thienyl)propionic acid (34.0 g); obtained in Example 8, was dissolved in chloroform (60 ml) and to this solution was added thionyl chloride (31.0 g), followed by a 30 minute-refluxing under heating. After the reaction, the solvent and remaining thionyl chloride was removed under reduced pressure. The remaining crude product was distilled under reduced pressure to obtain 2-methyl-2-(3-thienyl) propionic acid chloride with bp 86°-88° C./2.Otorr.
後処理
- customobtained in Example 8
- temperature-refluxing
- temperatureunder heating
- customAfter the reaction
- customwas removed under reduced pressure
- distillationThe remaining crude product was distilled under reduced pressure
出典と根拠
- ORDレコード
- ord-bf8e0204c9b448d0ba2e7a2f9d01c6c3
- 出典データセット
- uspto-grants-1994_03
- 特許番号
- US05296454
反応ノート
読み込み中…