1-Chloro-2-(trifluoromethyl)benzene → HCID 14373143、化合物

HRID 487750

反応式

HRID 487750 の反応式
Cl[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]([F:11])([F:10])[F:9].[CH:12]([C:15]1[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=1)([CH3:14])[CH3:13].C1(P(C2C=CC=CC=2)CCCCP(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[C:52](=O)([O-])[O-:53].[Na+].[Na+].[C]=O>[Pd](Cl)Cl>[F:9][C:8]([F:11])([F:10])[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[C:52]([O:21][C:18]1[CH:19]=[CH:20][C:15]([CH:12]([CH3:14])[CH3:13])=[CH:16][CH:17]=1)=[O:53]

参加物

7

反応物 5

HCID 69211-Chloro-2-(trifluoromethyl)benzeneHCID 74654-IsopropylphenolHCID 10340Sodium CarbonateHCID 821241,4-Bis(diphenylphosphino)butaneHCID 178418416HCID 178418416、化合物2 回

生成物 1

HCID 14373143HCID 14373143、化合物

試薬・触媒・溶媒 1

HCID 24290Palladium Chloride触媒

実験手順

In an autoclave made of a metal were placed 45.13 g of ortho-chlorobenzotrifluoride, 6.8 g of paraisopropylphenol, 88.5 mg of palladium chloride, 213 mg of 1,4-bisdiphenylphosphinobutane and 5.3 g of sodium carbonate. The air in the autoclave was replaced with carbon monoxide introduced thereinto in several times, after which carbon monoxide was further introduced to adjust its pressure therein to 30 kg/cm2. The internal temperature was adjusted to 190° C. on a salt bath and the reaction was carried out thereon with stirring for 4 hours.

後処理

  1. additionintroduced
  2. customThe internal temperature was adjusted to 190° C. on a salt bath

出典と根拠

ORDレコード
ord-4ad03a75e8a14f449f4b03d6aff53f4b
出典データセット
uspto-grants-1994_03
特許番号
US05296601

関連ノート

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