Methyl 4-nitropyridine-2-carboxylate → Methyl 4-aminopyridine-2-carboxylate

HRID 488454

反応式

HRID 488454 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][N:7]=[C:6]([C:10]([O:12][CH3:13])=[O:11])[CH:5]=1)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:9]=[CH:8][N:7]=[C:6]([C:10]([O:12][CH3:13])=[O:11])[CH:5]=1

参加物

4

反応物 1

HCID 3352523Methyl 4-nitropyridine-2-carboxylate

生成物 1

HCID 3759117Methyl 4-aminopyridine-2-carboxylate収率 94.1%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A solution of methyl 4-nitropyridin-2-ylcarboxylate (0.7 g) (Deady et. al., Aus. J. Chem. 24 (1971)385-390) in methanol (30 ml) was treated with 10% Pd/C (0.3 g) and stirred under hydrogen at atmospheric pressure overnight. The solution was filtered and evaporated to yield the title compound (0.55 g). NMR δ(CDCl3) 3.97(3H,s), 4.34(2H, broad), 6.65(1H,dd), 7.39(1H,d), 8.32(1H,d).

後処理

  1. filtrationThe solution was filtered
  2. customevaporated

出典と根拠

ORDレコード
ord-7f1060c725a74a8e9560e611ae4b9716
出典データセット
uspto-grants-2005_12
特許番号
US06972297B2

関連ノート

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