Diethylamine → 4-[(Diethylamino)methyl]benzoic acid

HRID 488541

反応式

HRID 488541 の反応式
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([OH:11])=[O:10])=[CH:5][CH:4]=1.[CH2:12]([NH:14][CH2:15][CH3:16])[CH3:13]>C(#N)C>[CH2:12]([N:14]([CH2:15][CH3:16])[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([OH:11])=[O:10])=[CH:5][CH:4]=1)[CH3:13]

参加物

4

反応物 2

HCID 8021DiethylamineHCID 742344-(Chloromethyl)benzoic acid

生成物 1

HCID 9485164-[(Diethylamino)methyl]benzoic acid収率 63%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

1 g (1 equivalent) of α-chloroparatoluic acid and 1.22 mL (2 equivalents) of diethylamine are placed in solution in 30 mL of acetonitrile. The reaction mixture is taken to reflux for 48 hours. The solvent is evaporated off under vacuum and the residue is purified by chromatography on silica gel column (CH2Cl2/MeOH 60/40 then pure MeOH). The product is obtained in the form of a white powder after precipitation from hexane. (Yield=63%).

後処理

  1. temperatureto reflux for 48 hours
  2. customThe solvent is evaporated off under vacuum
  3. customthe residue is purified by chromatography on silica gel column (CH2Cl2/MeOH 60/40
  4. customThe product is obtained in the form of a white powder
  5. customafter precipitation from hexane

出典と根拠

ORDレコード
ord-67b3606ed97745088224a32eb7d53c20
出典データセット
uspto-grants-2005_12
特許番号
US06972343B1

関連ノート

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