Pyridine → 4-(4-Chlorophenyl)-3-pyrrolidin-N-yl-butan-2-one Oxime

HRID 488606ノート

反応式

HRID 488606 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH:9]([N:13]2[CH2:17][CH2:16][CH2:15][CH2:14]2)[C:10](=O)[CH3:11])=[CH:4][CH:3]=1.N1C=CC=CC=1.Cl.[NH2:25][OH:26]>C(O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH:9]([N:13]2[CH2:17][CH2:16][CH2:15][CH2:14]2)[C:10](=[N:25][OH:26])[CH3:11])=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 1049PyridineHCID 443297Hydroxyamine hydrochlorideHCID 222704894-(4-Chlorophenyl)-3-(1-pyrrolidinyl)-butan-2-one

生成物 1

HCID 858679314-(4-Chlorophenyl)-3-pyrrolidin-N-yl-butan-2-one Oxime

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of 4-(4-chlorophenyl)-3-pyrrolidin-N-yl-butan-2-one (200 mg, 0.79 mmol, from Step B) dissolved in ethanol (2 mL), was added pyridine (63 mg, 0.79 mmol), and hydroxylamine hydrochloride (78 mg, 1.12 mmol). The mixture was refluxed for 24 h when LC/MS indicated disappearance of all starting material. The mixture was cooled to room temperature, concentrated under reduced pressure, treated with 33% aqueous potassium carbonated, and extracted with chloroform 5 times. The organic layers were combined and filtered over glass wool and dried over potassium carbonate. The filtrated obtained after passing through sintered glass was concentrated to give the oxime, homogeneous by TLC, Rf=0.3 in 95:5 CH2Cl2:MeOH. LC/MS m/e=267 (M+1). 500 MHz 1H NMR (CDCl3) δ 1.73 (m, 4H), 1.76 (s, 3H), 2.40 (m, 2H), 2.60 (m, 2H), 2.72 (dd, J=2.7, 10.8 Hz, 1H), 2.94 (dd, J=4.3, 8.8 Hz, 1H), 3.03 (dd, J=4.4, 13.3 Hz, 1H), 3.8 (s, 1H), 6.96 (d, J=8.3 Hz, 2H), 7.11 (d, J=8.3 Hz, 2H)

後処理

  1. temperatureThe mixture was refluxed for 24 h when LC/MS
  2. concentrationconcentrated under reduced pressure
  3. additiontreated with 33% aqueous potassium
  4. extractionextracted with chloroform 5 times
  5. filtrationfiltered over glass wool
  6. dry with materialdried over potassium carbonate
  7. customThe filtrated obtained
  8. concentrationwas concentrated

出典と根拠

ORDレコード
ord-4692341f00374e09b2e77888079ea8d8
出典データセット
uspto-grants-2005_12
特許番号
US06972295B2

反応ノート

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