Cyclohexane → 3-(3-bromopropyl)-1H-indole

HRID 488762

反応式

HRID 488762 の反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH2:10][CH2:11][CH2:12]O)=[CH:2]1.[Br:14]P(Br)(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.C1CCCCC1>O1CCOCC1>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH2:10][CH2:11][CH2:12][Br:14])=[CH:2]1

参加物

5

反応物 3

HCID 8078CyclohexaneHCID 70579Triphenylphosphine dibromideHCID 77115Indole-3-propanol

生成物 1

HCID 100371923-(3-bromopropyl)-1H-indole収率 99.4%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

To a solution of 2 g (11.41 mmol) of 3-(1H-indol-3-yl)propanol in 40 ml of dioxane was added at room temperature 5.3 g (12.55 mmol) of dibromotriphenylphosphorane and the resulting solution was stirred during 18 h. An excess of cyclohexane was added and the resulting precipitate was filtered and discarded. The solvent was evaporated to dryness to give 2.7 g (99%) of product as an oil which was used in the subsequent step without further purification.

後処理

  1. filtrationthe resulting precipitate was filtered
  2. customThe solvent was evaporated to dryness

出典と根拠

ORDレコード
ord-eeb14de8206a4951914cf43bcae514b2
出典データセット
uspto-grants-2005_12
特許番号
US06974819B2

関連ノート

読み込み中…