Sulfuric Acid → 2-hydroxyimino-N-phenylacetamide
反応式
[C:1]([NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)(=[O:6])[CH2:2]C(C)=O.[N:14]([O-])=[O:15].[Na+].S(=O)(=O)(O)O>[OH-].[Na+]>[OH:15][N:14]=[CH:2][C:1]([NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:6]参加物
5
反応条件
- 温度
- 0 °C
実験手順
Acetoacetanilide (25.0 g, 0.14 mol) and sodium nitrite (12.65 g, 0.18 mol) were dissolved in aqueous sodium hydroxide solution (140 ml, 1 N) and the resulting solution was added dropwise over 20 min to an aqueous solution of sulfuric acid (120 ml conc. H2SO4 in 950 ml water) cooled in an ice bath. The reaction mixture was stirred at 0° C. for 30 min, then the precipitate was filtered and washed with water to yield 2-hydroxyiminoacetanilide (22.64 g., 78% yield) as a pale yellow solid.
後処理
- temperaturecooled in an ice bath
- filtrationthe precipitate was filtered
- washwashed with water
出典と根拠
- ORDレコード
- ord-abc6f84208b84ffcba07207732b9c7ba
- 出典データセット
- uspto-grants-2005_12
- 特許番号
- US06974813B2
反応ノート
読み込み中…