Sulfuric Acid → 2-hydroxyimino-N-phenylacetamide

HRID 488790

反応式

HRID 488790 の反応式
[C:1]([NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)(=[O:6])[CH2:2]C(C)=O.[N:14]([O-])=[O:15].[Na+].S(=O)(=O)(O)O>[OH-].[Na+]>[OH:15][N:14]=[CH:2][C:1]([NH:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:6]

参加物

5

反応物 3

HCID 1118Sulfuric AcidHCID 7592AcetoacetanilideHCID 23668193Sodium Nitrite

生成物 1

HCID 63990632-hydroxyimino-N-phenylacetamide収率 98.5%

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒

反応条件

温度
0 °C

実験手順

Acetoacetanilide (25.0 g, 0.14 mol) and sodium nitrite (12.65 g, 0.18 mol) were dissolved in aqueous sodium hydroxide solution (140 ml, 1 N) and the resulting solution was added dropwise over 20 min to an aqueous solution of sulfuric acid (120 ml conc. H2SO4 in 950 ml water) cooled in an ice bath. The reaction mixture was stirred at 0° C. for 30 min, then the precipitate was filtered and washed with water to yield 2-hydroxyiminoacetanilide (22.64 g., 78% yield) as a pale yellow solid.

後処理

  1. temperaturecooled in an ice bath
  2. filtrationthe precipitate was filtered
  3. washwashed with water

出典と根拠

ORDレコード
ord-abc6f84208b84ffcba07207732b9c7ba
出典データセット
uspto-grants-2005_12
特許番号
US06974813B2

関連ノート

読み込み中…