Glycerol → Monostearin

HRID 489057

反応式

HRID 489057 の反応式
[OH:1][CH2:2][CH:3]([CH2:5][OH:6])[OH:4].N1C=CC=CC=1.[C:13](Cl)(=[O:31])[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH3:30].C([O-])(O)=O.[Na+]>CN(C=O)C>[C:13]([O:1][CH2:2][CH:3]([CH2:5][OH:6])[OH:4])(=[O:31])[CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH3:30]

参加物

6

反応物 4

HCID 753GlycerolHCID 1049PyridineHCID 8212Stearoyl chlorideHCID 516892Sodium Bicarbonate

生成物 1

HCID 24699Monostearin

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒2 回

実験手順

To a mixture of glycerol (30 g, 326 mmol) and pyridine (25 ml) dissolved in DMF (300 ml) was added dropwise stearoyl chloride (10 g, 33 mmol) dissolved in DMF 100 ml9. The mixture was cooled on an ice bath until addition was complete, whereupon the reaction was maintained under an N2 atmosphere overnight. After 15 hours CH2CL2 (300 ml) and saturated NaHCO3 (aq) was added. The phases were separated and the organic phase washed with water (50 ml) and dried with Na2SO4.

後処理

  1. temperatureThe mixture was cooled on an ice bath until addition
  2. temperaturewas maintained under an N2 atmosphere overnight
  3. customThe phases were separated
  4. washthe organic phase washed with water (50 ml)
  5. dry with materialdried with Na2SO4

出典と根拠

ORDレコード
ord-e0db80c15c0749028813e3ba995226be
出典データセット
uspto-grants-2005_12
特許番号
US06974802B2

関連ノート

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