Trifluoroacetic acid → HCID 67428691、化合物

HRID 490122ノート

反応式

HRID 490122 の反応式
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH3:8][N:9]([CH3:25])[C:10]([C@@H:12]1[CH2:16][C@@H:15]([F:17])[CH2:14][N:13]1C(OC(C)(C)C)=O)=[O:11]>C(Cl)(Cl)Cl>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:17][C@H:15]1[CH2:14][NH:13][C@H:12]([C:10]([N:9]([CH3:25])[CH3:8])=[O:11])[CH2:16]1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 67428750tert-butyl(2S,4R)-2-[(dimethylamino)carbonyl]-4-fluoropyrrolidine-1-carboxylate

生成物 1

HCID 67428691HCID 67428691、化合物

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

10.5 mL of trifluoroacetic acid was added under ice cooling to a 25 mL chloroform solution of 3.50 g of the compound obtained in step 1-2b, after which the reaction mixture was stirred for 3 hours at room temperature. The solvent was then distilled off under reduced pressure, which gave 7.27 g of residue (yellow oily substance). This compound was used in the following reaction without being purified.

後処理

  1. distillationThe solvent was then distilled off under reduced pressure, which

出典と根拠

ORDレコード
ord-41e6913884764ba088bed494a1fcd2e2
出典データセット
uspto-grants-2009_05
特許番号
US07528124B2

反応ノート

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