反応式
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[N:8]1([C:12]([C@@H:14]2[CH2:18][CH:17]([F:19])[CH2:16][N:15]2C(OC(C)(C)C)=O)=[O:13])[CH2:11][CH2:10][CH2:9]1>C(Cl)(Cl)Cl>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[N:8]1([C:12]([C@@H:14]2[CH2:18][CH:17]([F:19])[CH2:16][NH:15]2)=[O:13])[CH2:11][CH2:10][CH2:9]1参加物
4
実験手順
10 mL of trifluoroacetic acid was added under ice cooling to a 30 mL chloroform solution of 2.20 g of the compound obtained in step 7-2, after which the reaction mixture was stirred for 2 hours at room temperature. After this, the reaction mixture was concentrated under reduced pressure to obtain 3.82 g of residue (pale yellow oily substance). This compound was used in the following reaction without being purified.
後処理
- concentrationAfter this, the reaction mixture was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-f2ceda13e2484980918cc2ab2eda90e7
- 出典データセット
- uspto-grants-2009_05
- 特許番号
- US07528124B2
関連ノート
読み込み中…