Pyridine → 2-Oxo-2,3-dihydro-1H-indole-5-sulfonic acid (3-chlorophenyl)amide

HRID 49112

反応式

HRID 49112 の反応式
Cl[S:2]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][C:9](=[O:14])[CH2:8]2)(=[O:4])=[O:3].[Cl:15][C:16]1[CH:17]=[C:18]([CH:20]=[CH:21][CH:22]=1)[NH2:19].N1C=CC=CC=1>ClCCl>[Cl:15][C:16]1[CH:17]=[C:18]([NH:19][S:2]([C:5]2[CH:6]=[C:7]3[C:11](=[CH:12][CH:13]=2)[NH:10][C:9](=[O:14])[CH2:8]3)(=[O:4])=[O:3])[CH:20]=[CH:21][CH:22]=1

参加物

5

反応物 3

HCID 1049PyridineHCID 79323-ChloroanilineHCID 49625062-oxo-2,3-dihydro-1H-indole-5-sulfonyl chloride

生成物 1

HCID 90558432-Oxo-2,3-dihydro-1H-indole-5-sulfonic acid (3-chlorophenyl)amide収率 74%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A suspension of 5-chlorosulfonyl-2-oxindole (5 g), 3-chloroaniline (2.74 mL) and pyridine (3.5 mL) in dichloromethane (30 mL) was stirred at room temperature for overnight. The precipitate was filtered, washed with dichloromethane and dried to give 5.2 g (74%) 2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid (3-chloro-phenyl)-amide.

後処理

  1. filtrationThe precipitate was filtered
  2. washwashed with dichloromethane
  3. customdried

出典と根拠

ORDレコード
ord-b649366521aa48a78bd6a0663c7eaef1
出典データセット
uspto-grants-2004_03
特許番号
US06706709B2

関連ノート

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