Bromine → Diethyl 4-Bromo-2-methylbenzylphosphonate
反応式
[CH3:1][C:2]1[CH:16]=[CH:15][CH:14]=[CH:13][C:3]=1[CH2:4][P:5](=[O:12])([O:9][CH2:10][CH3:11])[O:6][CH2:7][CH3:8].[Br:17]Br>P(OC)(OC)(OC)=O.O>[CH3:1][C:2]1[CH:16]=[C:15]([Br:17])[CH:14]=[CH:13][C:3]=1[CH2:4][P:5](=[O:12])([O:9][CH2:10][CH3:11])[O:6][CH2:7][CH3:8]参加物
5
実験手順
10 g (42 mmol) of diethyl 2-methylbenzylphosphonate were dissolved in 60 ml of trimethyl phosphate and the solution was introduced into a flask protected from light and moisture. 16 g (0.05 mol) of Br2 were added dropwise, while stirring. The mixture was stirred at 90° C. for 15 hours and, after cooling, was diluted with 100 ml of water and extracted three times with 100 ml of n-hexane each time. The organic phase wa dried, concentrated and distilled.
後処理
- additionthe solution was introduced into a flask
- stirringThe mixture was stirred at 90° C. for 15 hours
- temperatureafter cooling
- extractionextracted three times with 100 ml of n-hexane each time
- customThe organic phase wa dried
- concentrationconcentrated
- distillationdistilled
出典と根拠
- ORDレコード
- ord-d600937ba404454f851cb18c5c96b0b1
- 出典データセット
- uspto-grants-1993_09
- 特許番号
- US05242908
反応ノート
読み込み中…