Water → HCID 69363687、化合物

反応式

[BH4-].[Na+].[O:3]([C:21]1[CH:28]=[C:27]([O:29][CH3:30])[C:24]([CH:25]=[O:26])=[C:23]([O:31][CH3:32])[CH:22]=1)[Si:4]([C:17]([CH3:20])([CH3:19])[CH3:18])([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.O>O1CCCC1>[O:3]([C:21]1[CH:22]=[C:23]([O:31][CH3:32])[C:24]([CH2:25][OH:26])=[C:27]([O:29][CH3:30])[CH:28]=1)[Si:4]([C:17]([CH3:20])([CH3:19])[CH3:18])([C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1)[C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1

参加物

実験手順

Sodium borohydride (519.0 mg, 13.73 mmol) was added to an ice-cold solution of 4-t-butyldiphenylsiloxy-2,6-dimethoxybenzaldehyde (3.85 g, 9.15 mmol) in tetrahydrofuran (40 mL), and the mixture was stirred at room temperature for 2 hours and 30 minutes. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford crude 4-t-butyldiphenylsiloxy-2,6-dimethoxybenzyl alcohol as a colorless crystalline powder (melting point: 127.5-129.0° C.) (4.01 g).