Thionyl Chloride → 1-(Chloromethyl)-4-propylbenzene

HRID 493036ノート

反応式

HRID 493036 の反応式
[CH2:1]([C:4]1[CH:11]=[CH:10][C:7]([CH2:8]O)=[CH:6][CH:5]=1)[CH2:2][CH3:3].S(Cl)([Cl:14])=O>C(Cl)(Cl)Cl>[CH2:1]([C:4]1[CH:11]=[CH:10][C:7]([CH2:8][Cl:14])=[CH:6][CH:5]=1)[CH2:2][CH3:3]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 2760472(4-Propylphenyl)methanol

生成物 1

HCID 122531731-(Chloromethyl)-4-propylbenzene収率 97%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

In 50 ml of chloroform was dissolved 8.63 g (57.5 mmol) of 4-n-propylbenzyl alcohol synthesized in the step (ii), and 8.10 g (68.1 mmol) of thionyl chloride was added to the mixture. The mixture was subjected to reaction at a room temperature for 24 hours. After the completion of the reaction, the chloroform phase was washed successively with an aqueous solution of sodium hydrogencarbonate and water. Chloroform was removed from the chloroform phase to give 9.40 g (55.8 mmol) of 4-n-propylbenzylchloride.

後処理

  1. additionwas added to the mixture
  2. customThe mixture was subjected to reaction at a room temperature for 24 hours
  3. customAfter the completion of the reaction
  4. washthe chloroform phase was washed successively with an aqueous solution of sodium hydrogencarbonate and water
  5. customChloroform was removed from the chloroform phase

出典と根拠

ORDレコード
ord-efb9c43b1460418aabf8d823c1a5a25b
出典データセット
uspto-grants-2009_05
特許番号
US07534547B2

反応ノート

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