Erythrose, 4-phosphate → D-erythritol 4-phosphate

HRID 493052ノート

反応式

HRID 493052 の反応式
[Na].[P:2]([O:6][CH2:7][C@@H:8]([OH:13])[C@@H:9]([OH:12])[CH:10]=[O:11])([OH:5])([OH:4])=[O:3].[BH4-].[Na+]>CO>[P:2]([O:6][CH2:7][C@@H:8]([OH:13])[C@@H:9]([OH:12])[CH2:10][OH:11])([OH:4])([OH:5])=[O:3]

参加物

5

反応物 3

HCID 122357Erythrose, 4-phosphateHCID 4311764Sodium borohydrideHCID 5360545Sodium

生成物 1

HCID 192838D-erythritol 4-phosphate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

The sodium salt of D-erythrose 4-phosphate (14.6 mg, 65.7 pmol) is dissolved in methanol (600 μl, 40% (v/v)). Sodium borohydride is added. The reaction is monitored by detection of the aldehyde according to the method of Stahl (Bollinger, H. R., Brenner, M., Gänshirt, H., Mangold, H. K., Seiler, H., Stahl, E. ad Waldi, D. (1964) IN: Dünnschicht-Chromatographie; Ein Laboratoriumshandbuch (ed. Stahl, E.) Springer Verlag, Berlin, Göttingen; Heidelberg). After consumption of the aldehyde the pH of the solution is adjusted with acetic acid to 4-5. The reaction mixture is lyophillized yielding D-erythritol 4-phosphate as a dry compound.

後処理

  1. customAfter consumption of the aldehyde the pH of the solution

出典と根拠

ORDレコード
ord-e425671040d64d4bbd0b13029651ea37
出典データセット
uspto-grants-2009_05
特許番号
US07534742B2

反応ノート

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