Hydrogen Bromide → 4-Hydroxy-4'-nitrobiphenyl

HRID 493512

反応式

HRID 493512 の反応式
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.Br>C(O)(=O)C>[OH:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][CH:10]=2)=[CH:7][CH:8]=1

参加物

4

反応物 2

HCID 260Hydrogen BromideHCID 111280794-Methoxy-4'-nitrobiphenyl

生成物 1

HCID 1380784-Hydroxy-4'-nitrobiphenyl

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
120 °C

実験手順

4′-Methoxy-4-nitro-biphenyl (4.55 g, 19.8 mmol), prepared in the previous step, in a mixture of glacial acetic acid plus 65 mL of 48% HBr was heated at approximately 120° C. until the reaction was complete by TLC. The reaction was concentrated under reduced pressure and the residue partitioned between diethyl ether and water. The organic layer was separated, dried (Na2SO4) and the solvent removed under reduced pressure to give 4′-hydroxy-4-nitro-biphenyl.

後処理

  1. concentrationThe reaction was concentrated under reduced pressure
  2. customthe residue partitioned between diethyl ether and water
  3. customThe organic layer was separated
  4. dry with materialdried (Na2SO4)
  5. customthe solvent removed under reduced pressure

出典と根拠

ORDレコード
ord-b96104b8c75c422aacbc263d6a4065c5
出典データセット
uspto-grants-2009_05
特許番号
US07534894B2

関連ノート

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