Triethylamine → 4-(Bis(4-chlorophenyl)methyl)piperazin-2-one

HRID 494052

反応式

HRID 494052 の反応式
Cl[CH:2]([C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=1)[C:3]1[CH:8]=[CH:7][C:6]([Cl:9])=[CH:5][CH:4]=1.[NH:17]1[CH2:22][CH2:21][NH:20][CH2:19][C:18]1=[O:23].C(N(CC)CC)C>CC#N>[Cl:9][C:6]1[CH:7]=[CH:8][C:3]([CH:2]([C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=2)[N:20]2[CH2:21][CH2:22][NH:17][C:18](=[O:23])[CH2:19]2)=[CH:4][CH:5]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 130784,4'-Dichlorobenzhydryl chlorideHCID 231360Piperazin-2-one

生成物 1

HCID 689317794-(Bis(4-chlorophenyl)methyl)piperazin-2-one収率 83.5%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

To a solution of chlorobis(4-chlorophenyl)methane (407 mg, 1.5 mmol) in MeCN was added piperazin-2-one (601 mg, 6.0 mmol) followed by triethylamine (626 μl, 4.5 mmol) and the resulting mixture was refluxed overnight. After cooling to rt, the solvent was evaporated to dryness and the residue was submitted to column chromatography (SiO2, DCM to DCM/MeOH=100:5) to give 4-(bis(4-chlorophenyl)methyl)piperazin-2-one (420 mg) as a white solid.

後処理

  1. temperaturethe resulting mixture was refluxed overnight
  2. customthe solvent was evaporated to dryness

出典と根拠

ORDレコード
ord-27f77bb0ef1241de99bd80c85f018621
出典データセット
uspto-grants-2009_05
特許番号
US07538114B2

関連ノート

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